Effects of pyrithiamin and oxythiamin on acetylcholine levels and utilization in rat brain.

Abstract

Regional cerebral acetylcholine (ACh) levels and utilization rate were assessed in vivo in rats rendered thiamin deficient using the thiamin antagonists pyrithiamin or oxythiamin. ACh levels were significantly reduced in all brain regions of pyrithiamin treated rats and in the medulla-pons and striatum of oxythiamin treated rats compared to controls. ACh… (More)

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@article{Vorhees1978EffectsOP, title={Effects of pyrithiamin and oxythiamin on acetylcholine levels and utilization in rat brain.}, author={Charles V Vorhees and Dennis E. Schmidt and Robert J. Barrett}, journal={Brain research bulletin}, year={1978}, volume={3 5}, pages={493-6} }