Effects of pyrenebutyrate on the translocation of arginine-rich cell-penetrating peptides through artificial membranes: recruiting peptides to the membranes, dissipating liquid-ordered phases, and inducing curvature.

@article{Katayama2013EffectsOP,
  title={Effects of pyrenebutyrate on the translocation of arginine-rich cell-penetrating peptides through artificial membranes: recruiting peptides to the membranes, dissipating liquid-ordered phases, and inducing curvature.},
  author={Sayaka Katayama and Ikuhiko Nakase and Yoshiaki Yano and Tomo Murayama and Yasushi Nakata and Katsumi Matsuzaki and Shiroh Futaki},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1828 9},
  pages={
          2134-42
        }
}
Arginine-rich cell-penetrating peptides, including octaarginine (R8) and HIV-1 TAT peptides, have the ability to translocate through cell membranes and transport exogenous bioactive molecules into cells. Hydrophobic counteranions such as pyrenebutyrate (PyB) have been reported to markedly promote the membrane translocation of these peptides. In this study, using model membranes having liquid-ordered (Lo) and liquid-disordered (Ld) phases, we explored the effects of PyB on the promotion of R8… CONTINUE READING
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