Effects of pulse strength and pulse duration on in vitro DNA electromobility.

@article{Zaharoff2004EffectsOP,
  title={Effects of pulse strength and pulse duration on in vitro DNA electromobility.},
  author={David A Zaharoff and Fan Yuan},
  journal={Bioelectrochemistry},
  year={2004},
  volume={62 1},
  pages={37-45}
}
Interstitial transport of DNA is a rate-limiting step in electric field-mediated gene delivery in vivo. Interstitial transport of macromolecules, such as plasmid DNA, over a distance of several cell layers, is inefficient due to small diffusion coefficient and inadequate convection. Therefore, we explored electric field as a novel driving force for interstitial transport of plasmid DNA. In this study, agarose gels were used to mimic the interstitium in tissues as they had been well… CONTINUE READING

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