Effects of puberty and diabetes on metabolism of insulin-sensitive fuels.

@article{Caprio1994EffectsOP,
  title={Effects of puberty and diabetes on metabolism of insulin-sensitive fuels.},
  author={Sonia Caprio and Gary Cline and Susan D Boulware and C Permanente and Gerald I Shulman and Robert S. Sherwin and William V Tamborlane},
  journal={The American journal of physiology},
  year={1994},
  volume={266 6 Pt 1},
  pages={E885-91}
}
Insulin's ability to stimulate glucose metabolism is reduced during normal puberty; these changes are exaggerated in adolescents with insulin-dependent diabetes mellitus (IDDM). Because the effects of puberty and IDDM on the other actions of insulin have not been established, we studied leucine kinetics (using [1-13C]leucine) and fat metabolism during euglycemic hyperinsulinemia (20 mU.m2.min-1) for 3 h in eight healthy and nine IDDM (HbA1 14 +/- 2%) adolescents and six healthy young adult… CONTINUE READING

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