Effects of psychotomimetic and antipsychotic agents on neocortical and striatal concentrations of various amino acids in the rat.

@article{Sakurai2004EffectsOP,
  title={Effects of psychotomimetic and antipsychotic agents on neocortical and striatal concentrations of various amino acids in the rat.},
  author={Shin-ichiro Sakurai and Sumikazu Ishii and Asami Umino and Dai Shimazu and Naoki Yamamoto and Toru Nishikawa},
  journal={Journal of neurochemistry},
  year={2004},
  volume={90 6},
  pages={1378-88}
}
A subcutaneous injection of small and moderate doses (1.6, 3.2, 4.0 and 4.8 mg/kg) of the schizophrenomimetic methamphetamine caused a dose-related increase in the tissue content (the net content) of L-Arg and L-Asn in the neocortex and striatum at 60 min, but not at 360 min, after injection. The methamphetamine-induced (4.8 mg/kg) increases in levels of these amino acids were significantly attenuated by pretreatment with an antipsychotic drug, haloperidol (1 mg/kg) or clozapine (10 mg/kg). In… CONTINUE READING

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