Effects of pseudophosphorylation mutants on the structural dynamics of smooth muscle myosin regulatory light chain.

@article{EspinozaFonseca2014EffectsOP,
  title={Effects of pseudophosphorylation mutants on the structural dynamics of smooth muscle myosin regulatory light chain.},
  author={L Michel Espinoza-Fonseca and Brett A. Colson and David D Thomas},
  journal={Molecular bioSystems},
  year={2014},
  volume={10 10},
  pages={2693-8}
}
We have performed 50 independent molecular dynamics (MD) simulations to determine the effect of pseudophosphorylation mutants on the structural dynamics of smooth muscle myosin (SMM) regulatory light chain (RLC). We previously showed that the N-terminal phosphorylation domain of RLC simultaneously populates two structural states in equilibrium, closed and open, and that phosphorylation at S19 induces a modest shift toward the open state, which is sufficient to activate smooth muscle. However… CONTINUE READING
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  • Paper Molecular BioSystems Published
  • 2014

PLoS One

  • H Rapp, E Klerman, C L Levine, Mcclendon
  • PLoS One
  • 2013

J. Biol. Chem. J. Struct. Biol

  • F Ni, B D Hong, J E Haldeman, K C Baker, C R Facemyer, Cremo
  • J. Biol. Chem. J. Struct. Biol
  • 2012

J. Mol. Biol

  • R Brito, L Alamo, +6 authors R Padron
  • J. Mol. Biol
  • 2011

Proc. Natl. Acad. Sci. U. S. A

  • A Stewart, K Franks-Skiba, S Chen, R Cooke
  • Proc. Natl. Acad. Sci. U. S. A
  • 2010

Biophys. J

  • M Espinoza-Fonseca, D Kast, D D Thomas
  • Biophys. J
  • 2007

J. Am. Chem. Soc

  • J Mandell, I Chorny, +4 authors M P Jacobson
  • J. Am. Chem. Soc
  • 2007

J. Comput. Chem

  • C Phillips, R Braun, +7 authors K Schulten
  • J. Comput. Chem
  • 2005

Proteins

  • A D Li, J H Robertson, Jensen
  • Proteins
  • 2005

J. Phys. Chem. B

  • P H Weber, J A Hünenberger, Mccammon
  • J. Phys. Chem. B
  • 2000

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