Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1

@article{Elia2008EffectsOP,
  title={Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1},
  author={Androulla Elia and Constantina Constantinou and Michael J. Clemens},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={811-822}
}
The availability of the eukaryotic polypeptide chain initiation factor 4E (eIF4E) for protein synthesis is regulated by the 4E-binding proteins (4E-BPs), which act as inhibitors of cap-dependent mRNA translation. The ability of the 4E-BPs to sequester eIF4E is regulated by reversible phosphorylation at multiple sites. We show here that, in addition, 4E-BP1… CONTINUE READING