Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs

Abstract

Purpose: We set out to measure drug binding to serum proteins. These have been shown to reduce the free plasma concentrations of a number of anticancer drugs, particularly of those of complex organic structure, in both experimental studies and clinical trials. Methods: We have used cultures of murine Lewis lung carcinoma cells as sensors of available drug… (More)
DOI: 10.1007/s002800051011

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