Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins.

Abstract

The Vesl-1S/Homer-1a proteins are upregulated during seizure and long-term potentiation, but are rapidly degraded by ubiquitin-proteasome systems under normal conditions. We examined the distribution of Vesl-1S proteins in cultured hippocampal neurons. Application of proteasome inhibitors caused accumulation of Vesl-1S immunoreactivity in the neurons which… (More)

Topics

  • Presentations referencing similar topics