Effects of protease inhibitors on the absorption of phenol red and fluorescein isothiocyanate dextrans from the rat intestine.

@article{Gotoh1996EffectsOP,
  title={Effects of protease inhibitors on the absorption of phenol red and fluorescein isothiocyanate dextrans from the rat intestine.},
  author={S. Gotoh and R. Nakamura and M. Nishiyama and Y. Quan and T. Fujita and A. Yamamoto and S. Muranishi},
  journal={Journal of pharmaceutical sciences},
  year={1996},
  volume={85 8},
  pages={
          858-62
        }
}
The absorption enhancement effects of three types of protease inhibitors, aprotinin, bacitracin, and soybean trypsin inhibitor, on the small and large intestinal absorption of phenol red (PR) and fluorescein isothiocyanate dextrans (FDs) were examined in rats. Of these protease inhibitors, only bacitracin enhanced the absorption of PR and FDs from the rat small and large intestine. Thus, we suggest that bacitracin has not only a protease-inhibitory but also an absorption-enhancing capability… Expand
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