Effects of propylthiouracil and methimazole on fetal thyroid status in mothers with Graves' hyperthyroidism.

@article{Momotani1997EffectsOP,
  title={Effects of propylthiouracil and methimazole on fetal thyroid status in mothers with Graves' hyperthyroidism.},
  author={Naoko Momotani and Jaeduk Yoshimura Noh and Naofumi Ishikawa and Kunihiko Ito},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 11},
  pages={3633-6}
}
Thionamide therapy is a mainstay of the treatment of hyperthyroidism complicated by pregnancy, but it can expose the fetus to hypothyroidism. In terms of fetal thyroid status, propylthiouracil (PTU) has been preferred over methimazole (MMI) based on experimental data on limited transplacental passage, and lower doses have been recommended. However, neither of these practices is supported by convincing clinical evidence. We compared the effect of maternal ingestion of PTU with that of MMI on… CONTINUE READING

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