Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells.

@article{Ji2012EffectsOP,
  title={Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells.},
  author={Yi Ji and Kai Li and Xianmin Xiao and Shan Zheng and Ting Xu and Siyuan Feng Chen},
  journal={Journal of pediatric surgery},
  year={2012},
  volume={47 12},
  pages={2216-23}
}
BACKGROUND/PURPOSE Propranolol, a non-selective beta-blocker, has recently been introduced as a novel treatment modality for proliferating hemangiomas. However, the mechanism of action of this therapy is unknown. In this study, we investigated propranolol in the etiology of hemangiomas that are associated with the proliferation and apoptosis of hemangioma-derived endothelial cells (HemECs). METHODS HemECs were isolated from freshly resected hemangioma specimens. We studied propranolol-treated… CONTINUE READING

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