Effects of propranolol and diltiazem on carnitine derivatives and acyl CoA in ischemic myocardium.

  title={Effects of propranolol and diltiazem on carnitine derivatives and acyl CoA in ischemic myocardium.},
  author={Jun Kamiya and Akira Kobayashi and N. Yamazaki},
  journal={Japanese circulation journal},
  volume={49 11},
The accumulation of intermediates subsequent to impaired beta-oxidation of free fatty acid (FFA) has been suggested as a cause of cellular damage in ischemic myocardium. We investigated the effects of propranolol and diltiazem on carnitine metabolism in ischemic myocardium. Propranolol (0.2 mg/kg/min, i.v.) and diltiazem (0.1 mg/kg/min, i.v.) were administered for 5 min, the administration started 10 min before coronary occlusion. ECGs were continuously recorded throughout the experiment… 



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It is suggested that the accumulation of long chain acyl carnitine may play an important role on cellular damage in ischemic myocardium and that administration of exogenous L-carnitine is beneficial for the protection of ischericular protection.

Effect of diltiazem, a calcium antagonist, on myocardial ischemia.

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The results suggest that the administration of L-carnitine may be beneficial to prevent serious arrhythmias in ischemic heart disease, presumably by restoring the imparied FFA oxidation.

Changes in tissue levels of carnitine and other metabolites during myocardial ischemia and anoxia.

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Myocardial infarction in the dog: effects of intravenous propranolol.

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