Effects of propranolol and diltiazem on carnitine derivatives and acyl CoA in ischemic myocardium.

@article{Kamiya1985EffectsOP,
  title={Effects of propranolol and diltiazem on carnitine derivatives and acyl CoA in ischemic myocardium.},
  author={Jun Kamiya and Akira Kobayashi and N. Yamazaki},
  journal={Japanese circulation journal},
  year={1985},
  volume={49 11},
  pages={
          1167-74
        }
}
The accumulation of intermediates subsequent to impaired beta-oxidation of free fatty acid (FFA) has been suggested as a cause of cellular damage in ischemic myocardium. We investigated the effects of propranolol and diltiazem on carnitine metabolism in ischemic myocardium. Propranolol (0.2 mg/kg/min, i.v.) and diltiazem (0.1 mg/kg/min, i.v.) were administered for 5 min, the administration started 10 min before coronary occlusion. ECGs were continuously recorded throughout the experiment… 

References

SHOWING 1-10 OF 29 REFERENCES

Effects of L-carnitine on tissue levels of acyl carnitine, acyl coenzyme A and high energy phosphate in ischemic dog hearts.

It is suggested that the accumulation of long chain acyl carnitine may play an important role on cellular damage in ischemic myocardium and that administration of exogenous L-carnitine is beneficial for the protection of ischericular protection.

Effect of diltiazem, a calcium antagonist, on myocardial ischemia.

Effects of L-carnitine on ventricular arrhythmias in dogs with acute myocardial ischemia and a supplement of excess free fatty acids.

The results suggest that the administration of L-carnitine may be beneficial to prevent serious arrhythmias in ischemic heart disease, presumably by restoring the imparied FFA oxidation.

Changes in tissue levels of carnitine and other metabolites during myocardial ischemia and anoxia.

Propranolol and experimental myocardial infarction: substrate effects.

It is suggested that the glucose-promoting and anti-lipolytic actions of propranolol might be important not only in decreasing infarct size but also in helping to prevent undesirable side effects in hearts with experimental myocardial infarction.

Myocardial infarction in the dog: effects of intravenous propranolol.

Electrophysiological Effects of Amphiphiles on Canine Purkinje Fibers

Both lysophosphoglycerides and long-chain acyl carnitines increase in isChemic tissue and induce profound electrophysiological derangements closely analogous to those seen in ischemic myocardium in vivo, implicating both metabolites as potential progenitors of dysrhythmias during ischemia.