Effects of propofol on cerebral hemodynamics and metabolism in patients with brain trauma.

@article{Pinaud1988EffectsOP,
  title={Effects of propofol on cerebral hemodynamics and metabolism in patients with brain trauma.},
  author={Michel Pinaud and J. N. Lelausque and Alain Ch{\'e}tanneau and N. Fauchoux and D J Menegalli and Remy Souron},
  journal={Anesthesiology},
  year={1988},
  volume={73 3},
  pages={
          404-9
        }
}
The authors determined the effect of propofol on cerebral blood flow, intracranial pressure, and cerebral arteriovenous oxygen content difference in severely brain-injured patients during orthopedic treatment of fractures of the extremities. The Glasgow Coma Scale score was 6 or 7 at the time of the study. Data were collected in the operating room before and during (5 and 15 min) administration of propofol (2 mg/kg iv bolus immediately followed by a 150 micrograms.kg-1.min-1 infusion) before… CONTINUE READING
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