Effects of propofol on cerebral blood flow and the metabolic rate of oxygen in humans.

@article{Oshima2002EffectsOP,
  title={Effects of propofol on cerebral blood flow and the metabolic rate of oxygen in humans.},
  author={Takashi Oshima and Fujio Karasawa and Tetsuo Satoh},
  journal={Acta anaesthesiologica Scandinavica},
  year={2002},
  volume={46 7},
  pages={831-5}
}
BACKGROUND Effects of propofol on human cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), and blood flow-metabolism coupling have not been fully evaluated. We therefore assessed the effects of propofol on total-CBF and CMRO2 in patients without noxious stimuli and neurologic disorders. METHODS General anesthesia was induced with midazolam (0.2 mg/kg) and fentanyl (5 microg/kg) in 10 patients (ASA physical status I) undergoing knee joint endoscopic surgery. Epidural… CONTINUE READING