Effects of propofol on cerebral blood flow, metabolism, and cerebral autoregulation in the anesthetized pig.

@article{Lagerkranser1997EffectsOP,
  title={Effects of propofol on cerebral blood flow, metabolism, and cerebral autoregulation in the anesthetized pig.},
  author={Mikael Lagerkranser and Kurt Martin Stange and Alf Sollevi},
  journal={Journal of neurosurgical anesthesiology},
  year={1997},
  volume={9 2},
  pages={188-93}
}
We studied the effects of propofol on the cerebral circulation and flow/pressure autoregulation in eight anesthetized pigs. Regional cerebral blood flow (rCBF) was measured with a cerebral venous outflow technique. Autoregulation was tested with angiotensin infusions and gradual blocks of the caval vein for hyper- and hypotensive challenges, respectively. Propofol was given in a bolus of 2.5 mg.kg-1 followed by an infusion starting at 12 mg.kg-1.h-1 and gradually reduced to 8 mg.kg-1.h-1. As… CONTINUE READING
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