Effects of propofol on N-methyl-D-aspartate receptor-mediated calcium increase in cultured rat cerebrocortical neurons.

@article{Grasshoff2005EffectsOP,
  title={Effects of propofol on N-methyl-D-aspartate receptor-mediated calcium increase in cultured rat cerebrocortical neurons.},
  author={Christian Grasshoff and Thomas Gillessen},
  journal={European journal of anaesthesiology},
  year={2005},
  volume={22 6},
  pages={467-70}
}
BACKGROUND AND OBJECTIVE The intravenous anaesthetic propofol has been reported to exert neuroprotective actions by several mechanisms. This study has been designed to investigate the effects of propofol on intracellular calcium increase in cultured cerebrocortical neurons after exposure to pathological concentrations of N-methyl-D-aspartate (NMDA) mediated by potential direct interactions of propofol with NMDA receptors. METHODS The effects of propofol (0.1-100 micromol) on intracellular… CONTINUE READING
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