Effects of promethazine on nocturnal sleep in normal man

  title={Effects of promethazine on nocturnal sleep in normal man},
  author={Ann -Marie Risberg and Jarl Risberg and David H. Ingvar},
The effects of a phenothiazine, promethazine, on sleep in ten healthy volunteers were investigated in two double blind polygraphic studies. The first part consisted of a single dose study with promethazine 50, 100, and 200 mg, using pentobarbital 100 mg as a reference substance. In the second part, four subjects spent 20 consecutive nights with nine drug nights (promethazine 100 mg), followed by a placebo withdrawal period of six nights, in the sleep laboratory. Promethazine showed a dose… CONTINUE READING