Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation.

@article{Donker1984EffectsOP,
  title={Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation.},
  author={Ab J. M. Donker and Rocco C. Venuto and Adrian O. Vladutiu and Jan R. Brentjens and Giuseppe A. Andres},
  journal={Clinical immunology and immunopathology},
  year={1984},
  volume={30 1},
  pages={142-55}
}
D-Penicillamine and captopril, two drugs that induce autoimmune manifestations in man, were administered orally for 5 to 10 months to various strains of rats. Three to eight weeks after D-penicillamine administration in a dosage of 20 to 50 mg per day, 73% of Brown Norway (BN) rats became ill. The disease was characterized by weight loss, dermatitis, and a high mortality presumably caused by disseminated intravascular coagulation. Microscopy revealed widespread granulomatous and necrotic… CONTINUE READING

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