Effects of prolactin and dihydrotestosterone upon the rat prostate gland.

@article{Thomas1976EffectsOP,
  title={Effects of prolactin and dihydrotestosterone upon the rat prostate gland.},
  author={James A. Thomas and M S Manandhar and Edward Keenan and W D Edwards and Patricia A. Klase},
  journal={Urologia internationalis},
  year={1976},
  volume={31 4},
  pages={
          265-71
        }
}
The simultaneous subcutaneous injections of dihydrotestosterone (0.5 mg/kg) and/or ovine prolactin (5 or 50 IU/kg) to mature castrate rats for periods of 5-10 days led to an augmentation of prostate gland levels of RNA, DNA and protein. Of the various lobes of the prostate gland, the dorsal portion seemed to be particularly sensitive to the effects of the combined hormone treatment. In general, the highest dose of prolactin (50 IU/kg) and the longer duration of administration (10 days) produced… CONTINUE READING