Effects of prohormone supplementation in humans: a review.

@article{Ziegenfuss2002EffectsOP,
  title={Effects of prohormone supplementation in humans: a review.},
  author={Tim N. Ziegenfuss and John M Berardi and Lonnie M. Lowery},
  journal={Canadian journal of applied physiology = Revue canadienne de physiologie appliquee},
  year={2002},
  volume={27 6},
  pages={
          628-46
        }
}
Despite a relative dearth of information on their effects, supplementation with prohormones has become a popular practice. Unlike synthetic anabolic-androgenic steroids, many of these over-the-counter androgens are produced endogenously by adrenal, gonadal and peripheral steroidogenic pathways as part of the normal sexual and reproductive hormonal milieu. It has been contended that peripheral enzymatic conversion of these prohormones to testosterone or nortestosterone (via ingestion of… Expand
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Androstenedione supplementation is unlikely to provide male athletes with any anabolic benefit and, with heavy resistance exercise, elevates estrogen. Expand
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TLDR
It is suggested that enhanced aromatization of androstenedione due to an increased adipose tissue mass may account for the high plasma estrogen levels observed in obese men. Expand
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