Effects of progesterone on human spermatozoa prepared for in-vitro fertilization.

@article{Emiliozzi1996EffectsOP,
  title={Effects of progesterone on human spermatozoa prepared for in-vitro fertilization.},
  author={Cl{\'e}lia Emiliozzi and H{\'e}l{\`e}ne Cordonier and Jean François Gu{\'e}rin and Brigitte Ciapa and M Bencha{\"i}b and Patrick F{\'e}nichel},
  journal={International journal of andrology},
  year={1996},
  volume={19 1},
  pages={
          39-47
        }
}
Progesterone has been tested in vitro with human spermatozoa to verify its physiological effects and its possible therapeutic use in cases of male infertility. Progesterone induced a rapid, dose-dependent influx of calcium in capacitated and non-capacitated spermatozoa with a half-maximally effective dose of 30 nM. The agonist, 19-nortestosterone, was much less potent that progesterone itself. Progesterone-induced calcium influx was not inhibited by a similar concentration (0.1 microgram/ml) of… 
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TLDR
Sperm responsiveness to progesterone is impaired in subfertile patients and is strictly correlated to the ability of fertilize the oocyte, and can be clinically useful for the preliminary assessment of the male partner to select the appropriate assisted reproductive technique.
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TLDR
Sperm responsiveness to progesterone is impaired in subfertile patients and is strictly correlated to the ability of fertilize the oocyte, and can be clinically useful for the preliminary assessment of the male partner to select the appropriate assisted reproductive technique.
Effect of human sperm exposure to progesterone on sperm-oocyte fusion and sperm-zona pellucida binding under various experimental conditions.
TLDR
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TLDR
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Effect of Progesterone on Bovine Sperm Capacitation and Acrosome Reaction1
TLDR
A potential role of P is demonstrated in bovine sperm AR but not in capacitation, and the presence of P in the media did not affect the membrane cholesterol efflux potential of the BSP-A1/-A2 proteins.
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TLDR
It is found that progesterone stimulates sperm PKC activity and that PKC inhibition with staurosporine and bisindolylmaleimide partially reversed the effect of progester one on acrosome reaction, indicating an involvement of the enzyme in the effectof the steroid.
Protein tyrosine phosphorylation is associated with capacitation of human sperm in vitro but is not sufficient for its completion.
TLDR
Protein tyrosine phosphorylation is associated with in vitro capacitation and could represent an important step in this process by priming the transductive pathways that are activated during exocytosis.
Versatile Action of Picomolar Gradients of Progesterone on Different Sperm Subpopulations
TLDR
The results suggest a versatile role of the gradual distribution of very low doses of progesterone, which selectively stimulate the priming and the acrosome reaction in different sperm subpopulations.
Detection of partial and complete acrosome reaction in human spermatozoa: which inducers and probes to use?
TLDR
A crossover investigation of the types of inducers and probes required for detecting partial or complete AR in human spermatozoa suggests that spontaneous AR as well as AR induced by progesterone, PMA and FF are partial.
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