Effects of progesterone blockade over cocaine-induced genital reflexes of paradoxical sleep-deprived male rats

@article{Andersen2005EffectsOP,
  title={Effects of progesterone blockade over cocaine-induced genital reflexes of paradoxical sleep-deprived male rats},
  author={M{\^o}nica Levy Andersen and S{\'e}rgio Tufik},
  journal={Hormones and Behavior},
  year={2005},
  volume={47},
  pages={477-484}
}
Paradoxical sleep deprivation (PSD) enhances cocaine-induced genital reflexes (penile erection [PE] and ejaculation [EJ]) in male rats and induces a significant increase in progesterone concentration. As progesterone treatment facilitates PE in PSD castrated rats, we may speculate that progesterone appears to be a relevant hormonal factor eliciting genital reflexes in PSD males. In order to expand the latter finding, different doses of antiprogestin mifepristone (vehicle, 2.5, 5, 10, and 20 mg… CONTINUE READING