Effects of probenecid on brain-cerebrospinal fluid-blood distribution kinetics of E-Delta 2-valproic acid in rabbits.

@article{Scism1997EffectsOP,
  title={Effects of probenecid on brain-cerebrospinal fluid-blood distribution kinetics of E-Delta 2-valproic acid in rabbits.},
  author={Jamie L. Scism and Karen M Powers and Alan A. Artru and Alexandra Chambers and Lidianys Lewis and Kimberly K Adkison and Thomas F Kalhorn and Danny D. Shen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1997},
  volume={25 12},
  pages={1337-46}
}
E-Delta 2-valproic acid (E-Delta 2-VPA), a major active metabolite of VPA, has been proposed as an alternative to VPA because it is less hepatotoxic and is nonteratogenic. In rodents, VPA and E-Delta 2-VPA have a brain tissue/free plasma concentration ratio less than unity, which suggests rapid removal of the alkanoate anticonvulsants from the central nervous system. This study in rabbits employed a simultaneous iv infusion-ventriculocisternal (VC) perfusion technique to investigate the steady… CONTINUE READING

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