Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210.

@article{Straus1971EffectsOP,
  title={Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210.},
  author={Marc J. Straus and Nathan Mantel and Abraham Goldin},
  journal={Cancer research},
  year={1971},
  volume={31 10},
  pages={
          1429-33
        }
}
Summary This study was conducted to determine whether priming dose schedules of methotrexate (MTX) could result in increased antileukemic effectiveness. CDF1 mice received i.p. inoculations of 105 L1210 ascites tumor cells. Beginning 2 days after leukemic inoculation (i.p.), the animals were treated with MTX (i.p.) on a series of dose schedules. In each experiment, a number of geometrically spaced doses of MTX were used at the first treatment, and each was followed by various geometrically… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

In Vivo Leukemic Cell Kill Kinetics and "Curability" in Experimental Systems. In: The Proliferation and Spread of Neoplastic Cells

F. M. Schabel, Jr.
  • M. D. Anderson Hospital and Tumor Institute
  • 1968
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

The Use of Growth Kinetics in Planning "Curative" Chemotherapy of Advanced Solid Tumors

F. M. Schabel, Jr.
  • Cancer Res.,
  • 1969
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Quantitative Studies of the Mitotic Cycle. In: The Proliferation and Spread of Neoplastic Cells

J. E. Sisken
  • M. D. Anderson Hospital and Tumor Institute
  • 1968
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cytokinetic analysis of tumor growth.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1966
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Kinetics of tumor cell proliferation.

  • Bulletin of the New York Academy of Medicine
  • 1966
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL