• DOI:10.3109/03639045.2014.938080
Corpus ID: 32460608

Effects of preparing techniques and aging on dissolution behavior of the solid dispersions of NF/Soluplus/Kollidon SR: identification and classification by a combined analysis by FT-IR spectroscopy and computational approaches

@article{Li2015EffectsOP,
  title={Effects of preparing techniques and aging on dissolution behavior of the solid dispersions of NF/Soluplus/Kollidon SR: identification and classification by a combined analysis by FT-IR spectroscopy and computational approaches},
  author={X. Li and Chuan Jiang and Lili Pan and H. Zhang and Lang Hu and Tianxue Li and X. Yang},
  journal={Drug Development and Industrial Pharmacy},
  year={2015},
  volume={41},
  pages={14 - 2}
}

X. Li, Chuan Jiang, +4 authors X. Yang

Published 2015

Materials Science, Medicine

Drug Development and Industrial Pharmacy

Abstract Context: Pharmaceutical solid dispersions are known to be seriously affected by issues of aging and processing. Objective: This study investigated the spectral patterns in the solid dispersions (SD) of Nifedipine/Soluplus/Kollidon SR and the feasibility of the methodology in identification and evaluation of the solid dispersions. Methods: The SD samples were prepared by hot melt extrusion (HMESD), solvent-evaporation (SESD), and fusion-cooling (FCSD). In order to distinguish the… CONTINUE READING

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