Effects of preparing techniques and aging on dissolution behavior of the solid dispersions of NF/Soluplus/Kollidon SR: identification and classification by a combined analysis by FT-IR spectroscopy and computational approaches

@article{Li2015EffectsOP,
  title={Effects of preparing techniques and aging on dissolution behavior of the solid dispersions of NF/Soluplus/Kollidon SR: identification and classification by a combined analysis by FT-IR spectroscopy and computational approaches},
  author={X. Li and Chuan Jiang and Lili Pan and H. Zhang and Lang Hu and Tianxue Li and X. Yang},
  journal={Drug Development and Industrial Pharmacy},
  year={2015},
  volume={41},
  pages={14 - 2}
}
  • X. Li, Chuan Jiang, +4 authors X. Yang
  • Published 2015
  • Materials Science, Medicine
  • Drug Development and Industrial Pharmacy
  • Abstract Context: Pharmaceutical solid dispersions are known to be seriously affected by issues of aging and processing. Objective: This study investigated the spectral patterns in the solid dispersions (SD) of Nifedipine/Soluplus/Kollidon SR and the feasibility of the methodology in identification and evaluation of the solid dispersions. Methods: The SD samples were prepared by hot melt extrusion (HMESD), solvent-evaporation (SESD), and fusion-cooling (FCSD). In order to distinguish the… CONTINUE READING
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    References

    SHOWING 1-10 OF 63 REFERENCES
    Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers.
    • J. Huang, Y. Li, +4 authors N. Shah
    • Materials Science, Medicine
    • International journal of pharmaceutics
    • 2011
    • 20
    Influence of different polymers on crystallization tendency and dissolution behavior of cilnidipine in solid dispersions
    • 17
    In vitro and in vivo evaluation of fenofibrate solid dispersion prepared by hot-melt extrusion
    • 66