Effects of preparing techniques and aging on dissolution behavior of the solid dispersions of NF/Soluplus/Kollidon SR: identification and classification by a combined analysis by FT-IR spectroscopy and computational approaches
@article{Li2015EffectsOP, title={Effects of preparing techniques and aging on dissolution behavior of the solid dispersions of NF/Soluplus/Kollidon SR: identification and classification by a combined analysis by FT-IR spectroscopy and computational approaches}, author={X. Li and Chuan Jiang and Lili Pan and H. Zhang and Lang Hu and Tianxue Li and X. Yang}, journal={Drug Development and Industrial Pharmacy}, year={2015}, volume={41}, pages={14 - 2} }
Abstract Context: Pharmaceutical solid dispersions are known to be seriously affected by issues of aging and processing. Objective: This study investigated the spectral patterns in the solid dispersions (SD) of Nifedipine/Soluplus/Kollidon SR and the feasibility of the methodology in identification and evaluation of the solid dispersions. Methods: The SD samples were prepared by hot melt extrusion (HMESD), solvent-evaporation (SESD), and fusion-cooling (FCSD). In order to distinguish the… CONTINUE READING
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