Corpus ID: 1092018

Effects of prenylamine on cardiac membrane currents and contractility.

@article{Haas1975EffectsOP,
  title={Effects of prenylamine on cardiac membrane currents and contractility.},
  author={H. G. Haas and R. Kern and C. Benninger and H. Einw{\"a}chter},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1975},
  volume={192 3},
  pages={
          688-701
        }
}
The influence of prenylamine on the electrical and mechanical activity of frog atrial muscle fibers has been studied under voltage clamp conditions. At a concentration of 10-4 M, prenylamine blocks the action potential without much affecting the resting potential. The drug depresses the peak transient sodium conductance with a dissociation constant of 1.7 times 10-5 M and on a one-to-one stoichiometric basis. The curve relating peak sodium conductance to membrane potential is slightly shifted… Expand
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