Effects of prenylamine on cardiac membrane currents and contractility.
@article{Haas1975EffectsOP, title={Effects of prenylamine on cardiac membrane currents and contractility.}, author={Hans G. Haas and R. Kern and C. Benninger and H. M. Einw{\"a}chter}, journal={The Journal of pharmacology and experimental therapeutics}, year={1975}, volume={192 3}, pages={ 688-701 } }
The influence of prenylamine on the electrical and mechanical activity of frog atrial muscle fibers has been studied under voltage clamp conditions. At a concentration of 10-4 M, prenylamine blocks the action potential without much affecting the resting potential. The drug depresses the peak transient sodium conductance with a dissociation constant of 1.7 times 10-5 M and on a one-to-one stoichiometric basis. The curve relating peak sodium conductance to membrane potential is slightly shifted…
23 Citations
The effects of prenylamine on single ventricular myocytes of guinea‐pig
- BiologyBritish journal of pharmacology
- 1988
It is concluded that prenylamine has a direct effect on cardiac calcium channels, not mediated by adrenoceptor activation, and was thus not due to indirect changes in endogenous catecholamine action.
The effects of amphotericin B on the ionic currents on frog atrial trabeculae.
- BiologyJournal of molecular and cellular cardiology
- 1977
Effects of histamine on electrical and mechanical activity in voltage-clamped frog atrial fibres.
- BiologyJournal of molecular and cellular cardiology
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Effect of lidoflazine on membrane currents and contraction in voltage-clamped frog atrial fibers.
- BiologyEuropean journal of pharmacology
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Transmembranäre Einwärtsströme bei der Erregung des Herzens
- Chemistry, BiologyKlinische Wochenschrift
- 2005
The existence of 2 separate channels in the ventricular myocardium allows selective alteration of contractility without concomitant changes of the Na-dependent excitation process or, conversely, the reduction of excitability whereas the Ca current remains unchanged.
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- BiologyThe Journal of physiology
- 1976
The carrier model suggests the occurrence of a depolarization‐induced inward transfer of Ca which might be involved in the generation of tonic contractions, and implies a strong asymmetry in the rate constants governing the chemical reactions on both sides of the membrane.
[Transmembrane inward currents during excitation of the heart (author's transl)].
- Biology, MedicineKlinische Wochenschrift
- 1975
The existence of 2 separate channels in the ventricular myocardium allows selective alteration of contractility without concomitant changes of the Na-dependent excitation process or, conversely, the reduction of excitability whereas the Ca current remains unchanged.
Effects of TTX and verapamil on the upstroke components of the action potential from the atrioventricular node of the rabbit.
- Biology, MedicineJournal of molecular and cellular cardiology
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Effect of phentolamine, alprenolol and prenylamine on maximum rate of rise of action potential in guinea-pig papillary muscles
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 2004
It is suggested that the drug molecules associate with the open sodium channels and dissociate slowly from the closed channels and that the inactivation parameter in the drug-associated channels is shifted in the hyperpolarizing direction.
PRENYLAMINE‐INDUCED CONTRACTURE OF FROG SKELETAL MUSCLE
- BiologyBritish journal of pharmacology
- 1977
The results suggest that prenylamine not only alters calcium mobility but also membrane permeability to other ions.