Corpus ID: 1092018

Effects of prenylamine on cardiac membrane currents and contractility.

@article{Haas1975EffectsOP,
  title={Effects of prenylamine on cardiac membrane currents and contractility.},
  author={H. G. Haas and R. Kern and C. Benninger and H. Einw{\"a}chter},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1975},
  volume={192 3},
  pages={
          688-701
        }
}
The influence of prenylamine on the electrical and mechanical activity of frog atrial muscle fibers has been studied under voltage clamp conditions. At a concentration of 10-4 M, prenylamine blocks the action potential without much affecting the resting potential. The drug depresses the peak transient sodium conductance with a dissociation constant of 1.7 times 10-5 M and on a one-to-one stoichiometric basis. The curve relating peak sodium conductance to membrane potential is slightly shifted… Expand
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23 Citations
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Background Citations
2
Methods Citations
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Results Citations
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23 Citations

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Citation Type

The effects of prenylamine on single ventricular myocytes of guinea‐pig
TLDR
It is concluded that prenylamine has a direct effect on cardiac calcium channels, not mediated by adrenoceptor activation, and was thus not due to indirect changes in endogenous catecholamine action. Expand
The effects of amphotericin B on the ionic currents on frog atrial trabeculae.
The effect of amphotericin B (1.3, 2.6, and 5.2 μ m ) on the ionic currents determining the cardiac action potential was investigated in the frog atrial trabecula. The experiments were performed with… Expand
Effects of histamine on electrical and mechanical activity in voltage-clamped frog atrial fibres.
TLDR
The positive inotropic effect of histamine on the tonic component of contraction seems to be secondary to the enhancement of [Na] i . Expand
Effect of lidoflazine on membrane currents and contraction in voltage-clamped frog atrial fibers.
TLDR
The data suggest that lidoflazine's antifibrillatory properties are less pronounced than those of classical antiarrhythmic agents; but the slight antifibillatory and negative inotropic effect might be helpful in the treatment of angina pectoris. Expand
Transmembranäre Einwärtsströme bei der Erregung des Herzens
TLDR
The existence of 2 separate channels in the ventricular myocardium allows selective alteration of contractility without concomitant changes of the Na-dependent excitation process or, conversely, the reduction of excitability whereas the Ca current remains unchanged. Expand
Calcium‐sodium antagonism on the frog's heart: a voltage‐clamp study.
TLDR
The carrier model suggests the occurrence of a depolarization‐induced inward transfer of Ca which might be involved in the generation of tonic contractions, and implies a strong asymmetry in the rate constants governing the chemical reactions on both sides of the membrane. Expand
[Transmembrane inward currents during excitation of the heart (author's transl)].
TLDR
The existence of 2 separate channels in the ventricular myocardium allows selective alteration of contractility without concomitant changes of the Na-dependent excitation process or, conversely, the reduction of excitability whereas the Ca current remains unchanged. Expand
Effects of TTX and verapamil on the upstroke components of the action potential from the atrioventricular node of the rabbit.
TLDR
The hypothesis that the fast sodium channel is present in the membrane of nodal cells and that the upstroke of the nodal action potential results from the activation of two inward currents is supported, but the fast inward current contributes less to depolarization in nodal than in atrial fibers because of the low resting potential of the former. Expand
Effect of phentolamine, alprenolol and prenylamine on maximum rate of rise of action potential in guinea-pig papillary muscles
  • H. Sada
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
It is suggested that the drug molecules associate with the open sodium channels and dissociate slowly from the closed channels and that the inactivation parameter in the drug-associated channels is shifted in the hyperpolarizing direction. Expand
PRENYLAMINE‐INDUCED CONTRACTURE OF FROG SKELETAL MUSCLE
TLDR
The results suggest that prenylamine not only alters calcium mobility but also membrane permeability to other ions. Expand
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