• Corpus ID: 1092018

Effects of prenylamine on cardiac membrane currents and contractility.

@article{Haas1975EffectsOP,
  title={Effects of prenylamine on cardiac membrane currents and contractility.},
  author={Hans G. Haas and R. Kern and C. Benninger and H. M. Einw{\"a}chter},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1975},
  volume={192 3},
  pages={
          688-701
        }
}
The influence of prenylamine on the electrical and mechanical activity of frog atrial muscle fibers has been studied under voltage clamp conditions. At a concentration of 10-4 M, prenylamine blocks the action potential without much affecting the resting potential. The drug depresses the peak transient sodium conductance with a dissociation constant of 1.7 times 10-5 M and on a one-to-one stoichiometric basis. The curve relating peak sodium conductance to membrane potential is slightly shifted… 
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It is concluded that prenylamine has a direct effect on cardiac calcium channels, not mediated by adrenoceptor activation, and was thus not due to indirect changes in endogenous catecholamine action.
Transmembranäre Einwärtsströme bei der Erregung des Herzens
TLDR
The existence of 2 separate channels in the ventricular myocardium allows selective alteration of contractility without concomitant changes of the Na-dependent excitation process or, conversely, the reduction of excitability whereas the Ca current remains unchanged.
Calcium‐sodium antagonism on the frog's heart: a voltage‐clamp study.
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The carrier model suggests the occurrence of a depolarization‐induced inward transfer of Ca which might be involved in the generation of tonic contractions, and implies a strong asymmetry in the rate constants governing the chemical reactions on both sides of the membrane.
[Transmembrane inward currents during excitation of the heart (author's transl)].
TLDR
The existence of 2 separate channels in the ventricular myocardium allows selective alteration of contractility without concomitant changes of the Na-dependent excitation process or, conversely, the reduction of excitability whereas the Ca current remains unchanged.
Effect of phentolamine, alprenolol and prenylamine on maximum rate of rise of action potential in guinea-pig papillary muscles
  • H. Sada
  • Biology, Chemistry
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
It is suggested that the drug molecules associate with the open sodium channels and dissociate slowly from the closed channels and that the inactivation parameter in the drug-associated channels is shifted in the hyperpolarizing direction.
PRENYLAMINE‐INDUCED CONTRACTURE OF FROG SKELETAL MUSCLE
TLDR
The results suggest that prenylamine not only alters calcium mobility but also membrane permeability to other ions.
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