Effects of prenatal caffeine administration on offspring mortality, open-field behavior and adult gastric ulcer susceptibility.


Pregnant rats were given caffeine (0.0%, 0.017%, 0.034% or 0.05%) in their drinking water throughout gestation. Offspring were cross-fostered to non-caffeine-treated mothers at birth. A dose-related increase in offspring mortality was observed at 24 hr and at 10 days post partum. Prenatal caffeine exposure did not significantly influence open-field… (More)