Effects of prenatal aflatoxin B1 exposure on behaviors of rat offspring.

  title={Effects of prenatal aflatoxin B1 exposure on behaviors of rat offspring.},
  author={Toshiharu Kihara and Takeshi Matsuo and Mineshi Sakamoto and Yoshiko Yasuda and Yasuhiro Yamamoto and T Tanimura},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={53 2},
The effects of prenatal aflatoxin B1 (AFB) exposure on eight behavioral parameters in Jcl:Wistar rat offspring were assessed. Pregnant rats were injected subcutaneously with 0.3 mg/kg/day of AFB dissolved in dimethylsulfoxide on days 11-14 (Group A) or 15-18 (Group B) of gestation. Controls received the vehicle similarly on days 11-18 of gestation. Before weaning, the offspring were examined using the cliff avoidance response (5 days of age), the negative geotaxis reflex (7 days), and swimming… CONTINUE READING

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