Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.

@article{Hebert2008EffectsOP,
  title={Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.},
  author={Mary F. Hebert and Thomas Easterling and Bridget Kirby and Daniel B. Carr and Megan L. Buchanan and Tricia Rutherford and Kenneth E. Thummel and Daniel P. Fishbein and Jashvant D. Unadkat},
  journal={Clinical pharmacology and therapeutics},
  year={2008},
  volume={84 2},
  pages={
          248-53
        }
}
  • Mary F. Hebert, Thomas Easterling, +6 authors Jashvant D. Unadkat
  • Published in
    Clinical pharmacology and…
    2008
  • Medicine
  • The objectives of the study were to evaluate the effects of pregnancy on CYP3A and P-glycoprotein (P-gp) activities, as measured by disposition of midazolam and digoxin, respectively. Thirteen women received digoxin (0.25 mg p.o.) and midazolam (2 mg p.o.) in random order, separated by 1-2 weeks at 28-32 weeks gestation, and the same order was repeated at 6-10 weeks postpartum. Plasma and urine concentrations were determined by liquid chromatography-mass spectrometry and analyzed by… CONTINUE READING

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