Effects of pregabalin on visceral pain responses and colonic compliance in rats.


BACKGROUND AND PURPOSE Pregabalin, which binds to the alpha2-delta subunit of voltage-gated calcium channels, increased the threshold for pain during colorectal distension (CRD) in irritable bowel syndrome (IBS) patients. We tested the effects of oral pregabalin on the visceral pain-related viscerosomatic and autonomic cardiovascular responses to CRD and… (More)
DOI: 10.1038/bjp.2008.259


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