Effects of preculture variability on clavulanic acid fermentation.

  title={Effects of preculture variability on clavulanic acid fermentation.},
  author={Andre' A Neves and Luis C. Vieira and Jos{\'e} Cardoso Menezes},
  journal={Biotechnology and bioengineering},
  volume={72 6},
The production profile of clavulanic acid by Streptomyces clavuligerus was shown to be strongly dependent on inoculum activity. Two sets of fermentations (A and B) were investigated at industrial pilot-plant scale using complex media. Type A fermentations were inoculated using late exponential growth phase mycelia. Type B fermentations were inoculated using mycelia harvested at stationary phase. Productivities throughout type A fermentations were consistently higher than type B, reaching a… CONTINUE READING