Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats

@article{Bruijnzeel2010EffectsOP,
  title={Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats},
  author={Adrie W. Bruijnzeel and Mahendra Bishnoi and Irma A. van Tuijl and Kim F. M. Keijzers and Kate R. Yavarovich and Tim M. Pasek and Jenna Ford and Jon C. Alexander and Hidetaka Yamada},
  journal={Psychopharmacology},
  year={2010},
  volume={212},
  pages={485-499}
}
Tobacco withdrawal is characterized by a negative mood state and relatively mild somatic symptoms. Increased noradrenergic transmission has been reported to play an important role in opioid withdrawal, but little is known about the role of noradrenergic transmission in nicotine withdrawal. The aim of these experiments was to investigate the effects of prazosin, clonidine, and propranolol on the negative mood state and somatic signs associated with nicotine withdrawal in rats. A discrete-trial… CONTINUE READING