Effects of powdered whole grapefruit and metoclopramide on the pharmacokinetics of cyclosporine in dogs.

@article{Radwanski2011EffectsOP,
  title={Effects of powdered whole grapefruit and metoclopramide on the pharmacokinetics of cyclosporine in dogs.},
  author={Noel E Radwanski and Rosario Cerundolo and Frances Shofer and Michael J. Hanley and Michael H. Court},
  journal={American journal of veterinary research},
  year={2011},
  volume={72 5},
  pages={687-93}
}
OBJECTIVE To determine whether oral administration of metoclopramide or a commercially available powdered whole grapefruit (PWG) nutraceutical in combination with cyclosporine enhances systemic availability of cyclosporine in dogs. SAMPLE 8 healthy mixed-breed dogs in part 1 and 6 of these 8 dogs in part 2. PROCEDURES Cyclosporine pharmacokinetics were determined over the course of 24 hours after oral administration of cyclosporine (5 mg/kg) alone, cyclosporine with metoclopramide (0.3 to 0… CONTINUE READING