Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves.

@article{Peacock1995EffectsOP,
  title={Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves.},
  author={John M. Peacock and Robin Orchardson},
  journal={Journal of dental research},
  year={1995},
  volume={74 2},
  pages={634-41}
}
Potassium ions in dentifrices for treating 'hypersensitive' dentin are believed to act directly on intradental nerves by raising extracellular potassium ion concentration ([K+]o) sufficiently to prevent action potential generation by axonal accommodation. However, the [K+]o necessary to block nerve conduction is not precisely known, nor is it certain that K+ can diffuse from a dentifrice in sufficient amounts to inactivate intradental nerves. To establish more accurately the [K+]o required to… CONTINUE READING
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