Effects of postoperative adjuvant chemotherapy on liver regeneration in partially hepatectomized rats

@article{Kohno1984EffectsOP,
  title={Effects of postoperative adjuvant chemotherapy on liver regeneration in partially hepatectomized rats},
  author={Hitoshi Kohno and Kiyoshi Inokuchi},
  journal={The Japanese journal of surgery},
  year={1984},
  volume={14},
  pages={515-523}
}
Five-fluorouracil (5-FU) was given to rats at various periods following two-thirds hepatectomy and the effects of this drug on the regenerating liver were investigated. In one group of rats, two-thirds hepatectomy was carried out (Group I). In four other groups, 20mg/kg 5-FU was given intravenously three times: 0, 24, 48 hours (Group II); 12, 36, 60 hours… CONTINUE READING