Effects of postnatal DES treatment on uterine growth, development, and estrogen receptor levels.

@article{Medlock1988EffectsOP,
  title={Effects of postnatal DES treatment on uterine growth, development, and estrogen receptor levels.},
  author={K. L. Medlock and Daniel M. Sheehan and Christina J Nelson and William S. Branham},
  journal={Journal of steroid biochemistry},
  year={1988},
  volume={29 5},
  pages={527-32}
}
The neonatal rodent appears to be an appropriate animal model for estrogen toxicity in the developing reproductive tract. Newborn rats were treated with diethylstilbestrol (DES) at human therapeutic doses (approx 1 mg/kg) during two ontogenetic periods (postnatal days 1-5 and 1-25). Treatment on days 1-5 doubled uterine wt by day 5; however, these uteri failed to grow after discontinuation of DES treatment. In contrast, uterine wt was 4-fold higher and DNA content was 2-fold higher than… CONTINUE READING