Effects of positively selected sequence variations in human and Macaca fascicularis beta-defensins 2 on antimicrobial activity.

@article{Antcheva2004EffectsOP,
  title={Effects of positively selected sequence variations in human and Macaca fascicularis beta-defensins 2 on antimicrobial activity.},
  author={Nikolinka Antcheva and Michele Boniotto and Igor Zelezetsky and Sabrina Pacor and Maria Vittoria Verga Falzacappa and Sergio Crovella and Alessandro Tossi},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 2},
  pages={685-8}
}
The evolution of orthologous genes coding for beta-defensin 2 (BD2) in primates has been subject to positive selection during the divergence of the platyrrhines from the catarrhines and of the Cercopithecidae from the Hylobatidae, great apes, and humans. Three peptides have been selected for a functional analysis of the effects of sequence variations on the direct antimicrobial activity: human BD2 (hBD2), Macaca fascicularis BD2 (mfaBD2), and a variant of the human peptide lacking Asp(4), (-D… CONTINUE READING