Effects of positive AMPA receptor modulators on calpain-mediated spectrin degradation in cultured hippocampal slices.

@article{Jourdi2005EffectsOP,
  title={Effects of positive AMPA receptor modulators on calpain-mediated spectrin degradation in cultured hippocampal slices.},
  author={Hussam Jourdi and Ted K. Yanagihara and Ulises Mart{\'i}nez and Xiaoning Bi and Gary Lynch and Michel Baudry},
  journal={Neurochemistry international},
  year={2005},
  volume={46 1},
  pages={
          31-40
        }
}
Positive modulators of AMPA receptors (AMPAr), also known as ampakines, are allosteric effectors of the receptors and have been extensively studied in past years due to their potential use as treatment for various diseases and ailments of the central nervous system such as mild cognitive impairment, schizophrenia, and Alzheimer's disease. Ampakines have been shown to improve performance on memory tasks in animals and in human subjects, an effect linked to their ability to increase agonist… CONTINUE READING
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