Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft.

@article{Lee2005EffectsOP,
  title={Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft.},
  author={Mei-Sze Lee and Judy Chan Yuet-Wa and Siu-Kai Kong and Biao Yu and Vincent Ooi Eng-Choon and Henry Wong Nai-Ching and Thomas Mak Chung-Wai and Kwok-pui Fung},
  journal={Cancer biology & therapy},
  year={2005},
  volume={4 11},
  pages={
          1248-54
        }
}
Paris polyphylla is a traditional Chinese Medical herb that has been used in treating cancer for thousands of year. Without studies on the anticancer effects of Paris polyphylla being initiated before, we have first studied the component of Paris polyphylla and have spotted out a steroidal saponin, polyphyllin D. As long as the chemical structure and the improved synthesis of polyphyllin D were ascertained, both in vitro to in vivo studies were performed. It was found that treatment of MCF-7… CONTINUE READING
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