Effects of polymer and surfactant on the dissolution and transformation profiles of cocrystals in aqueous media

@article{Alhalaweh2014EffectsOP,
  title={Effects of polymer and surfactant on the dissolution and transformation profiles of cocrystals in aqueous media},
  author={Amjad Alhalaweh and Hassan Refat H. Ali and Sitaram Velaga},
  journal={Crystal Growth \& Design},
  year={2014},
  volume={14},
  pages={643-648}
}
Capturing solubility advantages of cocrystals is of great interest, and thus to understand the mechanism by which different excipients could maintain the supersaturation generated by cocrystals at the course of absorption in aqueous media is essential. To achieve this aim, the impact of different excipients on dissolution behavior of indomethacin–saccharin (IND–SAC) were monitored by measuring the concentrations of cocrystal components in the absence and presence of various concentration of… 
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References

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The main objective of this study was to investigate the solubility behavior and solution chemistry of indomethacin–saccharin (IND–SAC) cocrystals in organic media. We also evaluated previously
Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds
TLDR
Cocrystallizations of exemestane and megestrol acetate from cocrystallization using various particle sizes improved initial dissolution rates compared to the respective original crystals.
Phase solubility diagrams of cocrystals are explained by solubility product and solution complexation
The purpose of this work was to develop a mathematical model that describes the solubility of cocrystals by taking into consideration the equilibria between cocrystal, cocrystal components, and
Dependence of cocrystal formation and thermodynamic stability on moisture sorption by amorphous polymer
The purpose of this study was to determine the influence of water vapor sorbed by and dissolved in an amorphous polymer on the formation and thermodynamic stability of cocrystals that are
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TLDR
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TLDR
By in-situ forming cocrystal, chemically stable amorphous solid dispersions were prepared by MM and HME at a depressed processing temperature, which provides an attractive opportunity for HME of heat-sensitive drugs.
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TLDR
Physical characterization showed that the IND–SAC cocrystal is unique vis-à-vis thermal, spectroscopic and X-ray diffraction properties, and were associated with a significantly faster dissolution rate than indomethacin (γ-form).
Engineering cocrystal thermodynamic stability and eutectic points by micellar solubilization and ionization
Pharmaceutical cocrystals are of great interest because of their potential to enhance solubility and bioavailability of poorly water-soluble drugs. Cocrystal development is however limited by their
Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability.
TLDR
In the case of the danazol:vanillin cocystal, using a combination of cocrystal, solubilizer, and precipitation inhibitor in a designed supersaturating drug delivery system resulted in a dramatic improvement in the bioavailability.
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