Effects of platelet-rich plasma-containing fragmin/protamine microparticles in enhancing endothelial and smooth muscle cell growth and inducing collateral vessels in a rabbit model of hindlimb ischemia.

@article{Fujita2013EffectsOP,
  title={Effects of platelet-rich plasma-containing fragmin/protamine microparticles in enhancing endothelial and smooth muscle cell growth and inducing collateral vessels in a rabbit model of hindlimb ischemia.},
  author={Mayumi Fujita and Takuya Horio and Satoko Kishimoto and Shingo Nakamura and Megumi Takikawa and Takefumi Nakayama and Yoritsuna Yamamoto and Masafumi Shimizu and Hidemi Hattori and Shoichi Tachibana and Mitsutaka Ishihara},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2013},
  volume={101 1},
  pages={
          36-42
        }
}
The purpose of the study was to evaluate the effects of isogenous platelet-rich plasma (PRP)-containing fragmin/protamine microparticles (F/P MPs) as a delivery system for proteins in PRP on growth of endothelial and smooth muscle cells (SMCs) in vitro and as an alternative treatment for peripheral arterial disease (PAD) and critical limb ischemia. Frozen and thawed PRP contains high concentrations of growth factors that are adsorbed by F/P MPs. Human aorta endothelial cells (AECs) and SMCs… CONTINUE READING
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