Effects of platelet-activating factor antagonist on preservation/reperfusion injury of the graft in porcine orthotopic liver transplantation.

@article{Takada1995EffectsOP,
  title={Effects of platelet-activating factor antagonist on preservation/reperfusion injury of the graft in porcine orthotopic liver transplantation.},
  author={Yoshihiro Takada and Karim Boudjema and Daniel Jaeck and M Bel-Haouari and M Doghmi and Marie Pierre Chenard and Philippe Wolf and Jacques Cinqualbre},
  journal={Transplantation},
  year={1995},
  volume={59 1},
  pages={10-6}
}
To investigate the role of platelet-activating factor (PAF) in the preservation/reperfusion injury of the liver graft, the effect of treatment with a potent PAF antagonist (E5880) was evaluated in a pig orthotopic liver transplantation model. The graft liver was flushed out and preserved for 8 hr at 4 degrees C using a simplified University of Wisconsin solution. The PAF antagonist was administered into the University of Wisconsin solution (1 mg/L), into the rinsing solution (1 mg/L), and to a… CONTINUE READING