Effects of plant extracts on HIV-1 protease.

@article{Filho2010EffectsOP,
  title={Effects of plant extracts on HIV-1 protease.},
  author={Jaime Ribeiro Filho and Heloina de Sousa Falc{\~a}o and Le{\^o}nia Maria Batista and Jos{\'e} Maria Barbosa Filho and Marcia Regina Piuvezam},
  journal={Current HIV research},
  year={2010},
  volume={8 7},
  pages={
          531-44
        }
}
Acquired immunodeficiency syndrome (AIDS) is one of the most important public health problems, affecting many people every day. This syndrome is caused by the human immunodeficiency virus (HIV) and the HIV-1 protease plays an essential role by promoting virus maturation and thus infecting new cells. The HIV-1 protease is one of the main targets for anti-HIV drug therapy. The present work is a literature survey of plant extracts whose activity has been studied on HIV-1 protease. Here we list 275… Expand
Inhibitory effect of aqueous dandelion extract on HIV-1 replication and reverse transcriptase activity
TLDR
The data suggest that dandelion extract has a potent inhibitory activity against HIV-1 replication and reverse transcriptase activity, and provides additional support for the potential therapeutic efficacy of Taraxacum officinale. Expand
A Review on Therapeutic Potential of Protease Inhibitors from Medicinal Plants
TLDR
This review focuses on therapeutic potential of plant protease inhibitors, which are of a particular concern at present due to their potent ability to inhibit protease enzymes that are involved in pathogenesis of various human diseases. Expand
Extracts of Moringa oleifera Lam . showing inhibitory activity against early steps in the infectivity of HIV-1 lentiviral particles in a viral vector-based screening
TLDR
M. oleifera leaf extracts showed potent and selective inhibition of early steps in HIV-1 infectivity and could serve as source of antiretroviral lead molecules, according to the outcome of this investigation. Expand
Computational prospecting for pharmacological mechanism of activity: HIV-1 inhibition by Ixoratannin-A2.
TLDR
A number of HIV-1 macromolecular targets including the multidrug resistant HIV protease enzyme, CXCR4 and the human elongin C protein were found to form sufficiently stable interaction with Ixoratannin A-2 and other natural products present in I. coccinea and which could possible explain the observed antiviral activity. Expand
Ellagic acid & gallic acid from Lagerstroemia speciosa L. inhibit HIV-1 infection through inhibition of HIV-1 protease & reverse transcriptase activity
TLDR
The active components responsible for anti-HIV activity were gallic acid and ellagic acid, through inhibition of reverse transcriptase and HIV protease, respectively and hence could be regarded as promising candidates for the development of topical anti-hIV-1 agents. Expand
Plant Natural Products as a Potential Source of Antimicrobial Agents: An Overview and a Glimpse on Recent Developments
TLDR
The very recent developments in the field of antimicrobial agents with an emphasis on antibacterial, antifungal, anti-parasitic and antiviral potentials (especially against Human Immunodeficiency virus and Influenza virus) and some of the other interesting recent developments are explored. Expand
Binding Insight of Anti-HIV Phytocompounds with Prime Targets of HIV: A Molecular Dynamics Simulation Analysis.
TLDR
It is concluded that Chebulic acid, Curcumin and Mulberroside C could be develop as envelope glycoprotein GP120 inhibitor, reverse transcriptase inhibitor and protease inhibitor respectively, however, the fluctuation of Che Bulic acid with respect to integrase and ribonuclease protein was higher during the simulation. Expand
Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010
TLDR
The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010, and the most studied type were the isoquinolines. Expand
Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer
TLDR
It is shown that natural products from plants continue to be a rich source of herbal medicines or biologically active compounds against cancer and Mechanisms of action, combination with chemotherapeutic drugs, and new technologies to increase activity and reduce the toxicity of the treatment are discussed. Expand
Indole Alkaloids from Marine Sources as Potential Leads against Infectious Diseases
TLDR
The aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 56 REFERENCES
Inhibitory Activities of Korean Plants on HIV-1 Protease
For the development of anti-AIDS agents, thirty-seven methanol extracts of Korean plant materials were tested for their inhibitory effects on human immunodeficiency virus type-1 (HIV-1) protease.Expand
A review of natural products with antileishmanial activity.
TLDR
A review of the literature on plant extracts and chemically defined molecules of natural origin showing antileishmanial activity and some aspects of recent antileishesmanial-activity-directed research on natural products are discussed. Expand
HIV protease inhibitors: their anti-HIV activity and potential role in treatment.
TLDR
Preclinical studies indicate that protease inhibitors prevent the maturation of immature viral particles into infectious virions and thereby limit the spread of HIV in cell cultures, and Laboratory data have also shown that these agents have good toxic-effect profiles, and recent improvements have resulted in compounds that are more bioavailable. Expand
Inhibition of growth of human immunodeficiency virus in vitro by crude extracts of Chinese medicinal herbs.
TLDR
Chinese medicinal herbs appeared to be a rich source of potentially useful materials for the treatment of human immunodeficiency virus infection. Expand
Inhibitory effects of Sudanese plant extracts on HIV‐1 replication and HIV‐1 protease
Forty‐eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV‐induced cytopathicExpand
Screening of various plant extracts used in ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 (HIV‐1) protease
TLDR
One of them, arecatannin B1 showed significant HIV‐1‐PR inhibitory activity and was shown by the A. catechu extract, from which some procyanidins were isolated. Expand
Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis.
TLDR
These compounds might contribute to anti-HIV-1 activities extracts of the medicinal plant Rhus chinensis and might target late-steps of HIV-1 life cycle. Expand
Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa.
TLDR
To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family plants were screened for their inhibitory effects against HIV-1 protease and Rosamultin isolated from the root of R. rugosa inhibited HIV- 1 protease by 53% at a concentration of 100 microM. Expand
Screening of Traditional Medicines for their Inhibitory Activity Against HIV‐1 Protease
TLDR
Aqueous extracts of 75 different traditional medicines, currently used for the treatment of various human diseases in China, Japan and Indonesia, were screened for possible inhibitory activity against HIV‐1 protease using fluorogenic assay, and 18 extracts inhibited HIV‐ 1 protease activity by more than 70%. Expand
Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease
To identify substances with anti‐human immunodeficiency virus (HIV) activity in traditional medicines, 101 extracts of Korean medicinal plants were screened for their inhibitory effects on HIV type 1Expand
...
1
2
3
4
5
...