Effects of placebos without deception compared with no treatment: A systematic review and meta‐analysis

@article{Charlesworth2017EffectsOP,
  title={Effects of placebos without deception compared with no treatment: A systematic review and meta‐analysis},
  author={James E. G. Charlesworth and Grace Petkovic and John Kelley and Monika Hunter and Igho J. Onakpoya and Nia Wyn Roberts and Franklin G. Miller and Jeremy Howick},
  journal={Journal of Evidence‐Based Medicine},
  year={2017},
  volume={10},
  pages={107 - 97}
}
To investigate the clinical efficacy of open‐label placebos compared with no treatment in a systematic review and meta‐analysis. 
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References

SHOWING 1-10 OF 54 REFERENCES
Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment
TLDR
A systematic review of 114 randomized trials that compared placebo‐treated patients with untreated patients could not confirm that placebo interventions induce powerful effects.
Effects of placebos without deception compared with no treatment: protocol for a systematic review and meta-analysis
TLDR
A protocol for the first systematic review and meta-analysis of studies of the effects of non-deceptive placebos compared with no treatment and the methods of delivery used for non- deceptively delivered placebos is presented.
Are Treatments More Effective than Placebos? A Systematic Review and Meta-Analysis
TLDR
Treatment and placebo effects were not different in 22 out of 28 predefined subgroup analyses, and when all criteria for reducing bias were ruled out (continuous outcomes) placebos were more effective than treatments.
Placebo Use in the United Kingdom: Results from a National Survey of Primary Care Practitioners
TLDR
Placebo use is common in primary care but questions remain about their benefits, harms, costs, and whether they can be delivered ethically, further research is required to investigate ethically acceptable and cost-effective placebo interventions.
Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome
TLDR
Whether open-label placebo is superior to a no-treatment control with matched patient-provider interactions in the treatment of irritable bowel syndrome (IBS) is tested and placebos administered without deception may be an effective treatment for IBS.
Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment.
TLDR
Although placebos had no significant effects on objective or binary outcomes, they had possible small benefits in studies with continuous subjective outcomes and for the treatment of pain.
Cochrane Handbook for Systematic Reviews of Interventions
The Cochrane Handbook for Systematic Reviews of Interventions is the official document that describes in detail the process of preparing and maintaining Cochrane systematic reviews on the effects of
Frequency and circumstances of placebo use in clinical practice - a systematic review of empirical studies
TLDR
Although the available evidence is incomplete and confusing at times there can be little doubt that the prevalence of placebo use outside of clinical trials is not negligible and that views and attitudes on placebos use differ considerably among individuals, both health care professionals and patients.
The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials
TLDR
The placebo effect is effective in the treatment of OA, especially for pain, stiffness and self-reported function, and the size of this effect is influenced by the strength of the active treatment, the baseline disease severity, the route of delivery and the sample size of the study.
Open-Label Placebo for Major Depressive Disorder: A Pilot Randomized Controlled Trial
TLDR
A pilot study investigating the feasibility of conducting trials of open-label placebo in adult outpatients with a primary diagnosis of non-psychotic MDD and the effect size for the main outcome measure (HAM-D-17) was medium, which is larger than typical effect sizes for the drug-placebo difference in MDD RCTs.
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