Effects of pirenzepine on lens-induced myopia in the guinea-pig

@inproceedings{Ch2003EffectsOP,
  title={Effects of pirenzepine on lens-induced myopia in the guinea-pig},
  author={Ouyang Ch and Chu Ry and Hu Wz},
  year={2003}
}
Objective To determine the efficacy of the M 1-selective muscarinic antagonist, pirenzepine, in preventing lens-induced myopia in the guinea-pig and to study the mechanism and the possibility of treatment of myopia with pirenzepine. Methods Fifteen 4-week-old guinea-pigs were monocularly fitted with -10.00 D lenses for a period of 11 days. In Group I (n=7), both eyes received topical administration of 0.24% saline vehicle as the controls. In Group II (n=8), the lens-fitted eyes were topically… CONTINUE READING

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