Effects of picrotoxin on light adapted frog electroretinogram are not due entirely to its action in proximal retina

@article{Popova2014EffectsOP,
  title={Effects of picrotoxin on light adapted frog electroretinogram are not due entirely to its action in proximal retina},
  author={Elka Popova},
  journal={Vision Research},
  year={2014},
  volume={101},
  pages={138-150}
}
In order to evaluate the site of action of picrotoxin (antagonist of ionotropic GABA receptors) on the electroretinographic (ERG) b- and d-waves, in this study we compared its effects on the intensity-response function of the ERG waves in intact light adapted frog eyecup preparations with its effects in eyecups, where the activity of proximal neurons was blocked by 1 mMN-methyl-d-aspartate (MNDA). Picrotoxin markedly enhanced the b- and d-wave amplitude and slowed the time course of the… CONTINUE READING

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