Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets.

@article{Liu2000EffectsOP,
  title={Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets.},
  author={Chun Liu and Xiang-dong Wang and Roderick Terry Bronson and Donald E. Smith and Norman I. Krinsky and Robert Russell},
  journal={Carcinogenesis},
  year={2000},
  volume={21 12},
  pages={2245-53}
}
There remains a remarkable discordance between the results of observational epidemiological studies and intervention trials using beta-carotene as a potential chemopreventive agent. One question that needs to be examined is whether the adverse outcomes of human beta-carotene trials are related to the large doses of beta-carotene that were administered. In the present study, ferrets were given a physiological (low) dose or a pharmacological (high) dose of beta-carotene supplementation (0.43 mg… CONTINUE READING
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