Effects of physiological aging on cardiac electrophysiology in perfused Fischer 344 rat hearts.

@article{Schmidlin1992EffectsOP,
  title={Effects of physiological aging on cardiac electrophysiology in perfused Fischer 344 rat hearts.},
  author={Olga Schmidlin and S. Rajaram Bharati and Meirovich Lev and Janice B Schwartz},
  journal={The American journal of physiology},
  year={1992},
  volume={262 1 Pt 2},
  pages={
          H97-105
        }
}
Aging effects on heart rate and atrioventricular (AV) conduction were studied in Langendorff-perfused hearts from 18 mature (4-6 mo), 12 middle-aged (12-14 mo), and 18 senescent (24-26 mo) Fischer 344 rats. Heart rate decreased with increasing age from 218 +/- 18 in mature to 196 +/- 27 (mean +/- SD) beats/min in middle-aged rats to 183 +/- 22 beats/min in senescent rats (analysis of variance, P less than 0.001). Spontaneous AV conduction time increased from 43 +/- 7 to 49 +/- 5 to 62 +/- 9 ms… CONTINUE READING
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