Effects of physical activity and age on mitochondrial function.

  title={Effects of physical activity and age on mitochondrial function.},
  author={Elizabeth J. Brierley and Margaret A T Johnson and Oliver James and Douglass Matthew Turnbull},
  journal={QJM : monthly journal of the Association of Physicians},
  volume={89 4},
It has been proposed that ageing results from the accumulation of mitochondrial DNA mutations with age which interfere with respiratory chain ATP production. Insufficient ATP production impairs cell function, and tissue dysfunction ensues, leading to morbidity, decline and eventually death. Supporting this theory, mitochondrial DNA mutations accumulate with age and respiratory chain function declines dramatically in human skeletal muscle. However, the extent of decline in respiratory chain… CONTINUE READING


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